Senin, 17 Oktober 2011

Virus Famili Tectiviridae

The Tectiviridae is a family of double stranded DNA viruses that infect bacteria and archea. Tectiviridae have no head-tail structure, but are capable of producing tail-like tubes of ~ 60 x 10 nm upon adsorption or after chloroform treatment. The name is derived from Latin tectus (meaning 'covered').

There is a single genus in this family - genus Tectivirus.

The type species is Enterobacteria phage PRD1.
Virology

This family of viruses consist of virons with double layers capsids that have apical spikes extending ~20 nanometers (nm) and an unusual internal lipid envelope around the nucleoprotein.

The capsid is nonenveloped and has a diameter of 63 nm icosahedron structure. The capsid shells are composed of two layers - an inner and outer capsid.

The inner capsid shell consist of a 5-6 nm flexible shell made from a lipoprotein vesicle whereas the outer capsid is made up of a smooth, rigid 3 nm thin protein shell. The outer shell has a pseudo T = 25 symmetry and consists of 240 capsid proteins trimers.

The genome is a single molecule of linear double stranded DNA of 15 kilobases in length. It forms a tightly packed coil and encodes several structural proteins. It encodes ~30 proteins that are transcribed in operons.

At least 9 structural proteins are present in the viron.

The genome is ~66 megaDaltons in weigh and constitutes 14-15% of the virion by weight. Lipids constitute a further 15% by weight. CarbohydratLife cycle

After adsorbion to the host's cells surface the viron extruds a tail-tube structure through a vertex for genome delivery into the host.

Capsid proteins polymerize around a lipoprotein vesicle translocated in the cytoplasm by virion assembly factors.

Mature virons are released by lysis.es are not present.

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